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Interest of £1,309,000 1year ended 31 December 2011: £1,096,000] was charged to Alliance Pharmaceuticals Limited on the total outstanding debt. During the year the Company re-invested £2,010,000 1year ended 31 December 2011: £5,300,000] in Alliance Pharmaceuticals Limited. During the year an amount of £369,000 1year end 31 December 2011: £179,000] was charged to Alliance Pharmaceuticals Limited by the Company for the employee share based payment. The amount owed by Alliance Pharmaceuticals Limited at the year end is £43,161,000 131 December 2011: £32,065,000].

At the year-end dividends declared by Alliance Pharmaceuticals Limited due to the Company of £10,000,000 for the year ended 31 December 2012 [for the year ended 31 December 2011: £2,000,000, for the year ended 31 December 2010: £7,000,000] are included within other receivables and are still outstanding. During on sale tramadol the year dividends of £2,000,000 were paid by Alliance Pharmaceuticals Limited to the Company. During the year the Group made payments on behalf of Unigreg of £377,000 1year ended 31 December 2011: £129,000], interest receivable from Unigreg was £48,000 1Year ended 31 December 2011: £48,000]. 33.Acquisitions Details of the acquisition of significant subsidiaries are given below. During the year the Group acquired 100% of the share capital of Opus Group Holdings Ltd 1"Opus"] for £8,040,000 plus the net asset value of the Opus Group which was £1,626,848.

In the twelve months to 31 March 2012 the turnover of Opus was £3.8m and the pretax profit, before directors' on sale tramadol emoluments, was £2.1m. The group incurred acquisition related costs of £206,000 that have been expensed to the income statement. Book of value Fair value of assets and assets and liabilities Fair value liabilities acquired adjustments acquired £000s £000s £000s Intangible fixed assets 3 8,040 8,043 Current assets 1excluding cash and cash equivalents] 1,045 - 1,045 Cash and cash equivalents 1,204 - 1,204 Current liabilities 1625] - (625) Net assets 1,627 8,040 9,667 Deferred tax liability - 11,849] (1,849) Goodwill - 1,849 1,849 Total consideration 1,627 8,040 9,667 Notes to the Financial Statements continued 66 for the year ended 31 December 2012 34. Joint Venture Name Principal Activity Country of Incorporation % Owned Unigreg Ltd Distribution of pharmaceutical products to China British Virgin Islands 60 The Group considered the existence of substantive participating rights held by the minority shareholder which provide that shareholder with a veto right over the significant financial and operating policies of Unigreg Ltd and determined that, as a result of these rights, the Group does not have control over the financial and operating policies of Unigreg Ltd, despite the Group's 60% ownership interest. The company is accounted for using the proportionate consolidation method of accounting.

The following amounts are included in the balance sheet and the income statement of the Group, being the Group's share of those items. Inter-company transactions are also eliminated proportionally. 31 December 31 December 1 January 2012 2011 2011 £000s £000s £000s Intangible fixed assets 1,950 1,950 1,950 Current assets 658 853 836 Current liabilities (145) (on sale tramadol 309] (600] Net assets 2,463 2,494 2,186 Year ended Year ended Year ended 31 December 31 December 31 December 2012 2011 2010 £000s £000s £000s Income 2,475 1,812 1,874 Cost of sales (1,415) (1,029] (1,033] Administration and marketing expense (239) (249] (276] Profit on ordinary activities before taxation 821 534 565 35. Ultimate controlling party There is no single ultimate controlling party. Shareholder enquiries The Company's share register is maintained on our behalf by Capita Registrars, who are responsible for updating the register, including details of changes to shareholders' addresses and purchases and sales of the Company's shares. If you have any questions about your on sale tramadol shareholding in the Company or need to notify any changes to your personal details you should write to Capita Registrars, Northern House, Woodsome Park, Fenay Bridge, Huddersfield, West Yorkshire HD8 0LA or telephone 0871 664 0300 (calls cost 10p per minute plus network extras, lines are open 9:00am to 5:30pm Monday to Friday).

Financial Calendar Annual General Meeting Final dividend record date Payment of final dividend Interim results announcement Year End Preliminary announcement 22 May 2013 14 June 2013 11 July 2013 11 September 2013 31 December 2013 March 2014 Shareholder Analysis Below is an analysis of the share register by size of holding as at 18 March 2013: Size of shareholding Proportion of shareholders Number of shares held Proportion of shares 1-5,000 29% 354,946 0.14% 5,001-10,000 17% 787,468 0.32% 10,001-50,000 35% 4,600,062 1.88% 50,001-100,000 5% 2,585,630 1.06% 100,001-500,000 5% 8,195,923 3.35% 500,001-1,000,000 3% 11,099,612 4.53% 1,000,001-5,000,000 4% 51,386,763 20.98% 5,000,001-10,000,000 1% 31,444,199 12.84% 10,000,001-50,000,000 1% 134,509,099 54.90% 100% 244,963,702 100% As at 18 March 2013 the Company has 584 registered shareholders.



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