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Upon reviewing the narra tive summaries of the serious adverse events, the reviewer concludes that 20/25 (80%) of the serious adverse events can be attributed to discontinuation of treatment with alprazolam XR and that 4/25 (16%) possibly can be attributed to discontinuation of alprazolam XR.

These serious events were: drug withdrawal syndrome (2); aggravated anxiety or panic (5); alprazolam overdose (1); insomnia (1); dizziness (2); confusion (2); xenical vs phentermine vs meridia disturbance of attention (1); tremor (1); headache (2); psychiatric d/o NOS (1); tearfulness (1); depressed mood (2); nausea & vomiting (2); and paresthesia (1).

Such adverse even ts were not unexpected in comparison to drug discontinuation adverse events observed with alprazolam IR and other benzodiazepines. None of these serious adverse events are unlabeled. Unexpected Serious Adverse Events For all of the Phase I-in studies, there were no unexpected or unlabeled serious adverse events, compared to those observed for treatment and drug discontinuation with alprazolam or other benzodiazepines F-3 Discontinuations Due to Adverse Events In Placebo-Controlled Trials Summary In the 5 placebo-controlled studies of alprazolam XR in Panic Disorder, the treatment- emergent adverse events most commonly leading to subject discontinuation in the alprazolam XR group during the treatment phase were sedation and somnolence. The drug discontinuation-emergent adverse events most commonly leading to study discontinuation in the alprazolam XR group were insomnia and aggravated anxiety. The study discontinuation profiles due to adverse events during the treatment and drug discontinuation phases are similar to the profiles observed with alprazolam IR treatment and discontinuation. In the alprazolam XR group, 17.14 % of subjects discontinued from the study due to ad verse events. In the placebo group, 7.74 % of subjects discontinued due to adverse events. In the alprazolam XR and placebo groups, 2.3% and 1.8% of subjects, respectively, discontinued from the treatment phase of the study due to serious adverse events. During the drag discontinuation phase, 0.7% of the alprazolam XR group and 0.4% of the placebo group discontinued from the study due to experiencing serious adverse events. Treatment Phase of Placebo-Controlled Trials In the alprazolam ]KR group, 91/531 (17.1%) subjects had > 1 treatment-emergent adverse event that led to discontinuation.

In the placebo group, 27/349 (7.buy generic xanax buy xanax alprazolam tablets 7%) had > 1 treatment-emergent adverse event that led to discontinuation. Thus, the rate of treatment-emergent adverse events that buy generic xanax buy xanax alprazolam tablets led to discontinuation in the alprazolam XR group was more than twice that in the placebo group.

The rate buy generic xanax buy xanax alprazolam tablets of adverse events that led to discontinuation was greatest for CNS adverse events (13.8% in the alprazolam XR group and 3.4% in the placebo group). The 5 adverse events most commonly leading to premature termina tion in the alprazolam XR group were sedation (7.5%), somnolence (3.2%), depression (2.5%), dysarthria (2.1%), and abnormal coordination (1.9%).



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