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The database currently contains data for 130 active pharmaceutical ingredients extracted from 172 different sources. For each test there is information about tested species, test method, tested concentrations, exposure duration, reported effects, and effect concentrations (LC50, EC50, or NOEC/LOEC). In this chapter an overview of the database structure and its contents is provided, and instructions on how to search the database and how to propose additional data are also given. Chapter 7 (The Swedish Environmental Classification and Information System for pharmaceuticals. An evaluation of the system's achievements so far, by Marlene Agerstrand and Christina Ruden) presents the results from a detailed buoys immap buy hydrocodone evaluation of the Swedish Environmental Classification and Information System for pharmaceuticals (SECIS).
In the chapter the system is introduced and an overview of the classifications made so far is reported. The classifications are also analyzed using the following questions: 1.How do the companies select data for classification purposes? Would additional data, from the scientific literature affect the companies' classifications? For these analyses all substances classified according to SECIS and for which there are data available in WikiPharma were buoys immap buy hydrocodone identified. In total 36 substances and 48 classifications (each substance can be classified by more than one company). Data from non-standard tests were used in only 6 of the 48 cases under scrutiny (12%).
In addition, short-term data are more abundant than data from long-term studies (79% short-term studies and 19% long-term buoys immap buy hydrocodone studies). In 42% of the analyzed assessments (20/48) data from the open scientific literature was referred to, and in 27 of the 48 cases company owned data were the only source of information. For each classification it was also investigated whether the data-set could be supplemented with information from the open scientific literature and whether a supplemented data-set would give rise to alternative classifications. This analysis showed that a supplemented data-set could change the risk assessment (PEC/PNEC) for 18 of the 48 assessments (37%), and the alternative assessment would have resulted in an altered risk classification in 13 of these 18 cases (72%). For 10 of these the risk category would have been higher compared to the classification based on the data-set that the company chose. Chapter 7 concludes by presenting three recommendations: 1.SECIS allows for both standard and non-standard test data when calculating PNEC 2.Long-term ecotoxicity data are preferred when calculating the PNEC 3. Companies are buoys immap buy hydrocodone recommended to take external ecotoxicity data into account when classifying buoys immap buy hydrocodone their products Chapter 8 (Swedish wastewater treatment plants and their ability to remove pharmaceuticals, by Per Falas and Jes la Cour Jansen) focus on existing Swedish wastewater treatment technologies and their ability to remove pharmaceuticals. In the early 1950s there were only a few wastewater treatment plants in Sweden but today there are more than 2 000 municipal plants designed to remove organic material and nutrients.
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