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Environmental risk assessment according to SECIS According com tramadol ultram ultracet to the SECIS guidance document the risk assessment within this system should follow the basic principle of environmental risk assessment, namely to combine information about the hazardous properties of an active pharmaceutical ingredient with its estimated (or measured) environmental concentrations to determine the PEC/PNEC ratio (Predicted Environmental Concentration / Predicted No Effect Concentration). The processes for environmental risk assessment for general chemicals and for pharmaceutical substances respectively are introduced in chapter 5. Within SECIS the PEC/PNEC ratio is used to classify each pharmaceutical product according to pre-defined criteria into a risk category an a risk phrase. The system has four categories for environmental risk and two categories for indicating lack of data.

For an overview and summary of these criteria see Table 1. (The Swedish Association of the Pharmaceutical Industry, 2007). SECIS classification order phentermine 30 criteria and the corresponding risk categories/risk phrases. SECIS Criteria Risk category PEC/PNEC 10 Use of the medicine has been considered to result in high environmental risk Data is lacking Risk of environmental impact cannot be excluded, since no ecotoxicity data are available Data availability is insufficient Risk of environmental impact cannot be excluded, however some ecotoxicity data are available The PEC value shall be calculated by using the formula and the basic principles specified by European Medicines order phentermine 30 Agency (EMA) (EMA, 2002).

It is also possible to use measured environmental order phentermine 30 concentrations (MEC) if sufficient data is available (The Swedish Association of the Pharmaceutical Industry, 2007). For the PNEC, the SECIS guidance document allows both for effect data originating from the companies' own studies and for data generated by other pharmaceutical companies or by independent research groups. All data should, ideally, be generated by methods supported by appropriate standards such as those issued by OECD (Organisation for Economic Co-operation and Development) or the FDA (United States Food and Drug Administration). The use of non-standard test data is however also permitted and companies are recommended to take data from the open scientific literature into account (The Swedish Association of the Pharmaceutical Industry, 2007). Experimental data should preferably be derived from longterm tests but the use of short-term data is allowed. Regardless of the test length, the data should originate from three trophic levels: algae, crustaceans and fish.

If data is available from the species believed to be most sensitive, based for example on understanding of receptor-mediated effects, a PNEC can be calculated with data from only one or two trophic levels.

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