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A27 C Ranitidine is a histamine receptor antagonist. It acts essentially on the H2 receptor and blocks acid production. Ranitidine is used in the treatment and prevention of ulcers, NSAID-induced ulcers, Zollinger-Ellison syndrome and gastro-oesophageal reflux disease. A28 A Acarbose is an intestinal a-glucosidase inhibitor that delays digestion and absorption of starch and sucrose. It is used in diabetes mellitus and is contraindicated in inflammatory bowel com multumcontent chlorpheniramine hydrocodone phenylephrine disease.
A29 E Rosiglitazone, a thiazolinedione used to treat diabetes mellitus, is contraindicated in patients with heart failure especially if taken in combination with insulin. A30 C Metformin is a biguanide used to treat diabetes mellitus. It is contraindicated in patients undergoing general anaesthesia since anaesthesia can interfere with renal function.
The risk of lactic acidosis associated with metformin increases in patients with renal impairment. Metformin should be stopped before and during surgery where anaesthesia is indicated. Metformin should only be restarted after the renal function has returned to normal. A31 B When polymorphism occurs, the molecules arrange themselves in two or more different ways in the crystal: either they may be packed differently in the crystal lattice, or there may be differences in the orientation or the conformation of the hydrocodone medication use molecules at the lattice site. These variations cause differences in X-ray diffraction patterns of the polymorphs and this technique is one of com multumcontent chlorpheniramine hydrocodone hydrocodone order overnight phenylephrine the main methods in detecting them. The polymorphs have different physical and chemical properties. A32 C For poorly soluble drugs, the com multumcontent chlorpheniramine hydrocodone phenylephrine digestive absorption depends on hydrocodone without apap their rate of dissolution.
Decreasing the particle size of these drugs to increase the surface-to- hydrocodoneapap hydrocodone bulk ratio improves their rate of dissolution.
A33 B Steroids and sterols represent an important class of drugs that are susceptible to oxidative degradation through the possession of alkene moieties. The oxidation of phenothiazines forms the sulfoxide moiety. A34 A Polymers have a number of applications in the development of formulations.
They have the properties drug interaction with tramadol of suspending agents, binding agents and emulsifying agents. They are included in formulations for the production of tablets, suspensions and emulsions. Polymers can be used as film coatings to disguise the unpleasant taste of a drug, to enhance drug stability and to modify drug release characteristics in modified-release preparations. A35 C Drug-protein binding is the reversible interaction of drugs with different proteins in plasma. The figure represents the chemical structure for paracetamol, which includes the N-(4-hydroxyphenyl) acetamide, derived from the interaction of p- aminophenol and an aqueous solution of acetic anhydride. The structure has two activating groups that make the benzene ring highly reactive toward electrophilic aromatic substitution.
A37 A After oral administration, paracetamol is completely absorbed from the gastrointestinal tract with peak plasma concentrations being reached in less than an hour. The drug is eliminated by conjugation with glucoronic acid in the liver. A38 A Paracetamol can be used in asthmatic patients (as opposed to non-steroidal anti-inflammatory drugs), in patients with com multumcontent chlorpheniramine hydrocodone phenylephrine a history of hypertension and in paediatric patients. A39 A The intermediate metabolites formed during the biotransformation in the liver are believed to be responsible for the hepatoxicity that results in overdosage.
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